259545 | Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem

259545
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₂₂N₄O₄S 150333-69-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      259545-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
          Catalogue Number259545
          Brand Family Calbiochem®
          SynonymsN1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
          References
          ReferencesLee, N.P., et al. 2010. Int J Cancer. 4, 968.
          Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
          Balabanov, S., et al. 2007. Blood. 4, 1701.
          Jakus, J., et al. 1993. J Biol Chem. 18, 13151.
          Product Information
          CAS number150333-69-0
          FormWhite powder
          Hill FormulaC₈H₂₂N₄O₄S
          Chemical formulaC₈H₂₂N₄O₄S
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity>95% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          259545

          References

          Reference overview
          Lee, N.P., et al. 2010. Int J Cancer. 4, 968.
          Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
          Balabanov, S., et al. 2007. Blood. 4, 1701.
          Jakus, J., et al. 1993. J Biol Chem. 18, 13151.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2012 JSW
          SynonymsN1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
          DescriptionA cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
          FormWhite powder
          CAS number150333-69-0
          Chemical formulaC₈H₂₂N₄O₄S
          Structure formulaStructure formula
          Purity>95% by NMR
          SolubilityH₂O (25 mg/ml; clear, colorless solution)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, N.P., et al. 2010. Int J Cancer. 4, 968.
          Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
          Balabanov, S., et al. 2007. Blood. 4, 1701.
          Jakus, J., et al. 1993. J Biol Chem. 18, 13151.