252750 Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem

252750
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₄₈N₆O₈·CH₄O₃S 138-14-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      252750-1GM
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          Plastic ampoule 1 gm
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          Description
          OverviewParenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.
          Catalogue Number252750
          Brand Family Calbiochem®
          SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
          References
          ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
          Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
          Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
          Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
          Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
          Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
          Product Information
          CAS number138-14-7
          FormFaint yellow powder
          Hill FormulaC₂₅H₄₈N₆O₈·CH₄O₃S
          Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity92.5-100% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUG5310000
          Safety Information
          R PhraseR: 22-36/37/38-40-42/43

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          252750

          References

          Reference overview
          Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
          Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
          Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
          Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
          Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
          Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2008 RFH
          SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
          DescriptionParenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.
          FormFaint yellow powder
          CAS number138-14-7
          RTECSUG5310000
          Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
          Structure formulaStructure formula
          Purity92.5-100% by TLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 2860
          ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
          Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
          Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
          Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
          Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
          Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.