251800 | Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem

251800
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₂₉NO₁₀ · HCl 23541-50-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      251800-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerases I and II. Induces DNA single-strand breaks. Also induces apoptosis in HeLa S3 tumor cells.
          Catalogue Number251800
          Brand Family Calbiochem®
          SynonymsDaunomycin, HCl
          References
          ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
          Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
          Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
          Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
          Bellec, F., et al. 1992. Flow Cytometry 13, 880.
          Product Information
          CAS number23541-50-6
          ATP CompetitiveN
          FormRed crystalline solid
          Hill FormulaC₂₇H₂₉NO₁₀ · HCl
          Chemical formulaC₂₇H₂₉NO₁₀ · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA synthesis, RNA synthesis
          PurityPotency: ≥840 µg/mg
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSHB7878000
          Safety Information
          R PhraseR: 22-40-42/43

          Harmful if swallowed.
          Limited evidence of a carcinogenic effect.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 22-36/37-45

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          251800

          References

          Reference overview
          Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
          Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
          Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
          Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
          Bellec, F., et al. 1992. Flow Cytometry 13, 880.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-June-2008 RFH
          SynonymsDaunomycin, HCl
          DescriptionPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.
          FormRed crystalline solid
          CAS number23541-50-6
          RTECSHB7878000
          Chemical formulaC₂₇H₂₉NO₁₀ · HCl
          Structure formulaStructure formula
          PurityPotency: ≥840 µg/mg
          SolubilityAqueous buffers, H₂O, or Methanol
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 2832
          ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
          Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
          Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
          Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
          Bellec, F., et al. 1992. Flow Cytometry 13, 880.