251650 Damnacanthal - CAS 477-84-9 - Calbiochem

251650
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀O₅ 477-84-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      251650-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
          Catalogue Number251650
          Brand Family Calbiochem®
          Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
          References
          ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
          Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
          Koumaglo, K., et al. 1992. Planta Med. 58, 533.
          Product Information
          CAS number477-84-9
          ATP CompetitiveN
          FormOrange-yellow solid
          Hill FormulaC₁₆H₁₀O₅
          Chemical formulaC₁₆H₁₀O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp56lck autophosphorylation
          Primary Target IC<sub>50</sub>17 nM against p56lck autophosphorylation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          251650

          References

          Reference overview
          Faltynek, C.R., et al. 1995. Biochemistry 34, 12404.
          Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
          Koumaglo, K., et al. 1992. Planta Med. 58, 533.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-April-2011 JSW
          Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
          DescriptionA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase activity. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck over PKA and PKC and >40 fold selectivity for p56lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lck over pp60src and pp59fyn. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells.
          FormOrange-yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number477-84-9
          Chemical formulaC₁₆H₁₀O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
          Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
          Koumaglo, K., et al. 1992. Planta Med. 58, 533.