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Description
Overview
A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.
Lee, S., et al. 2010. J. Neurophysiol.103, 1728. Honor, T., et al. 1998. Science.241, 701. Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49. Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.
Form
Dark brown solid
CAS number
2379-57-9
Chemical formula
C₈H₂N₄O₆Na₂
Structure formula
Purity
≥99% by HPLC
Solubility
H₂O (100 mM)
Storage
+2°C to +8°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Lee, S., et al. 2010. J. Neurophysiol.103, 1728. Honor, T., et al. 1998. Science.241, 701. Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49. Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.