260920 | DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem

260920
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₄N₂O₄ 32675-71-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      260920-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
          Catalogue Number260920
          Brand Family Calbiochem®
          Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
          References
          ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.
          Product Information
          CAS number32675-71-1
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₉H₁₄N₂O₄
          Chemical formulaC₁₉H₁₄N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCPG methylase M.Sssl
          Primary Target IC<sub>50</sub>115 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          260920

          References

          Reference overview
          Brueckner, B., et al. 2005. Cancer Res. 65, 6305.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
          DescriptionA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number32675-71-1
          Chemical formulaC₁₉H₁₄N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml) or Methanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.