288500 | DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem

288500
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₁₂F₂N₂O₂ · HCl · H₂O 96020-91-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      288500-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
          Catalogue Number288500
          Brand Family Calbiochem®
          SynonymsDFMO, Eflornithine, RMI-71782
          References
          ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
          Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
          Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
          Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
          Danzin, C., et al. 1979. Life Sci. 24, 519.
          Product Information
          CAS number96020-91-6
          ATP CompetitiveN
          FormWhite powder
          Hill FormulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
          Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetODC
          Purity≥99% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRM2981900
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          288500

          References

          Reference overview
          Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
          Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
          Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
          Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
          Danzin, C., et al. 1979. Life Sci. 24, 519.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-January-2008 JSW
          SynonymsDFMO, Eflornithine, RMI-71782
          DescriptionA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
          FormWhite powder
          CAS number96020-91-6
          RTECSRM2981900
          Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
          Structure formulaStructure formula
          Purity≥99% by TLC
          SolubilityH₂O (1 mg/ml) or Methanol (25 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 3522
          ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
          Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
          Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
          Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
          Danzin, C., et al. 1979. Life Sci. 24, 519.