251400 D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

251400
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₁₅OS₂ · K 83373-60-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      251400-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewSelective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
          Catalogue Number251400
          Brand Family Calbiochem®
          SynonymsTricyclodecan-9-yl-xanthogenate, K
          References
          ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
          Lozanski, G., et al. 1997. Biochem. J. 328, 271.
          Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
          Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
          Schutze, S., et al. 1992. Cell 71, 765.
          Sauer, G., et al. 1990. Cancer Lett. 53, 97.
          Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
          Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
          Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
          Product Information
          CAS number83373-60-8
          ATP CompetitiveN
          FormOff-white powder
          Hill FormulaC₁₁H₁₅OS₂ · K
          Chemical formulaC₁₁H₁₅OS₂ · K
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetpc-specificphopholipase c
          Primary Target K<sub>i</sub>5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          251400

          References

          Reference overview
          Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
          Lozanski, G., et al. 1997. Biochem. J. 328, 271.
          Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
          Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
          Schutze, S., et al. 1992. Cell 71, 765.
          Sauer, G., et al. 1990. Cancer Lett. 53, 97.
          Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
          Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
          Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-September-2010 JSW
          SynonymsTricyclodecan-9-yl-xanthogenate, K
          DescriptionSelective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).
          FormOff-white powder
          CAS number83373-60-8
          Chemical formulaC₁₁H₁₅OS₂ · K
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (25 mg/ml) and DMSO (25 mg/ml). Note: tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
          Toxicity Standard Handling
          ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
          Lozanski, G., et al. 1997. Biochem. J. 328, 271.
          Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
          Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
          Schutze, S., et al. 1992. Cell 71, 765.
          Sauer, G., et al. 1990. Cancer Lett. 53, 97.
          Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
          Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
          Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.