250255 Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

250255
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₃₇NO₆ 22144-77-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      250255-1MG
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          Glass bottle 1 mg
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          Description
          OverviewCell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776).
          Catalogue Number250255
          Brand Family Calbiochem®
          References
          ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
          Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
          Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
          Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
          Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
          Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
          Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
          Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
          Product Information
          CAS number22144-77-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₀H₃₇NO₆
          Chemical formulaC₃₀H₃₇NO₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetActin filament function
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGZ4850000
          Safety Information
          R PhraseR: 26/27/28-61

          Very toxic by inhalation, in contact with skin and if swallowed.
          May cause harm to the unborn child.
          S PhraseS: 3/7/9-22-36/37/39-45

          Keep container tightly closed, in a cool well ventilated place.
          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          250255

          References

          Reference overview
          Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
          Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
          Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
          Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
          Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
          Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
          Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
          Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

          Citations

          Title
        • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          DescriptionA cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Cytochalasin D also exhibits antibiotic and anti-tumor activity.
          FormWhite solid
          CAS number22144-77-0
          RTECSGZ4850000
          Chemical formulaC₃₀H₃₇NO₆
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (2 mg/ml) or Chloroform (2 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2790
          ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
          Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
          Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
          Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
          Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
          Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
          Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
          Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
          Citation
        • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.