240896 | Cystatin C, Human Urine - Calbiochem

240896
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      240896-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer.
          Catalogue Number240896
          Brand Family Calbiochem®
          SynonymsPost γ-globulin
          References
          ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
          Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
          Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
          Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
          Product Information
          ATP CompetitiveN
          FormSolid
          FormulationLyophilized from 20 mM NH₄HCO₃.
          ReversibleN
          Applications
          Biological Information
          Primary TargetCysteine protease
          Purity≥95% by SDS-PAGE
          SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          240896

          References

          Reference overview
          Hall, A., et al. 1998. Biochemistry 37, 4071.
          Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
          Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
          Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-June-2008 RFH
          SynonymsPost γ-globulin
          DescriptionA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (Ki = 0.26 nM) and cathepsin B (Ki = 4.4 nM). Thought to be linked to many disease processes including Alzheimer's Disease, hereditary cerebral hemorrhage and lung cancer.
          FormSolid
          FormulationLyophilized from 20 mM NH₄HCO₃.
          SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥95% by SDS-PAGE
          Solubility0.1 M sodium acetate buffer, pH 4.5
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
          Toxicity Standard Handling
          ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
          Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
          Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
          Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.