239777 Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem

239777
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      95076-93-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239777-100UG
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      Discontinued
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          Alu drum 100 μg
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          Description
          OverviewRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
          Catalogue Number239777
          Brand Family Calbiochem®
          SynonymsPeptidylproline cis-trans-Isomerase
          References
          ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
          Galat, A. 1993. Eur. J. Biochem. 216, 689.
          Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
          Luban, L., et al. 1993. Cell 73, 1067.
          Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
          Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
          Product Information
          CAS number95076-93-0
          ATP CompetitiveN
          EC number5.2.1.8
          FormLiquid
          FormulationIn 20 mM Tris-HCl, pH 7.8.
          ReversibleN
          Applications
          Biological Information
          Primary TargetCatalyzes the cis-trans-isomerization of X-Pro peptide bonds
          Purity≥90% by SDS-PAGE
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 24/25-36

          Avoid contact with skin and eyes.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239777

          References

          Reference overview
          Fruman, D.A., et al. 1994. FASEB J. 8, 391.
          Galat, A. 1993. Eur. J. Biochem. 216, 689.
          Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
          Luban, L., et al. 1993. Cell 73, 1067.
          Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
          Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-December-2008 RFH
          SynonymsPeptidylproline cis-trans-Isomerase
          DescriptionRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomeration of X-Pro-peptide bonds. Binds to proteins and acts as chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin is characterized by its binding to the immunosuppressant cyclosporin A. This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
          FormLiquid
          FormulationIn 20 mM Tris-HCl, pH 7.8.
          Concentration Label Please refer to vial label for lot-specific concentration
          CAS number95076-93-0
          EC number5.2.1.8
          Purity≥90% by SDS-PAGE
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
          Toxicity Standard Handling
          ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
          Galat, A. 1993. Eur. J. Biochem. 216, 689.
          Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
          Luban, L., et al. 1993. Cell 73, 1067.
          Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
          Kofron, J.L., et al. 1991. Biochemistry 30, 6127.