504480 Conantokin G - CAS 93438-65-4 - Calbiochem

Highly selective, potent, non-competitive antagonist of NR2B-containing NMDAR channels (Ki = 800 nM).

Conantokin G - CAS 93438-65-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Gly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH2

Primary Target: NMDA receptors
504480
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂ 93438-65-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04480.0001
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          		 Glass bottle 100 μg
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          Description
          OverviewThe most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 µM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems.
          Catalogue Number504480
          Brand Family Calbiochem®
          SynonymsGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH2
          References
          ReferencesSheng, Z., et al. 2007. Neuropharmacology. 53, 145.
          Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
          Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
          Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
          Mena, E., et al. 1990. Neurosci Lett. 118, 241.
          Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.
          Product Information
          CAS number93438-65-4
          FormWhite powder
          Hill FormulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
          Chemical formulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target K<sub>i</sub>0.8 µM
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide ContentY
          Peptide SequenceGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sheng, Z., et al. 2007. Neuropharmacology. 53, 145.
          Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
          Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
          Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
          Mena, E., et al. 1990. Neurosci Lett. 118, 241.
          Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-September-2014 JSW
          SynonymsGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH2
          DescriptionThe most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 µM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems.
          FormWhite powder
          CAS number93438-65-4
          Chemical formulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
          Peptide SequenceGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH₂
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSheng, Z., et al. 2007. Neuropharmacology. 53, 145.
          Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
          Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
          Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
          Mena, E., et al. 1990. Neurosci Lett. 118, 241.
          Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.