234501 | Compound 401 - CAS 168425-64-7 - Calbiochem

234501
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₅N₃O₂ 168425-64-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234501-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
          Catalogue Number234501
          Brand Family Calbiochem®
          Synonyms2-(Morpholin-1-yl)pyrimido[2,1-a]isoquinolin-4-one
          References
          ReferencesBallou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
          Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.
          Product Information
          CAS number168425-64-7
          FormBeige solid
          Hill FormulaC₁₆H₁₅N₃O₂
          Chemical formulaC₁₆H₁₅N₃O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          234501

          References

          Reference overview
          Ballou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
          Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-September-2008 RFH
          Synonyms2-(Morpholin-1-yl)pyrimido[2,1-a]isoquinolin-4-one
          DescriptionA cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number168425-64-7
          Chemical formulaC₁₆H₁₅N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBallou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
          Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.