219365 | Coagulation Factor V, Human Plasma

219365
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219365-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewNative coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca2+, and membrane phospholipids are cofactors that form a "prothrombinase" complex with Factor X, enabling its proteolytic activation of prothrombin to thrombin.
          Catalogue Number219365
          Brand Family Calbiochem®
          SynonymsProaccelerin, Labile Factor, Ac-globulin, Ac-g
          References
          ReferencesWalker, F.J. 1992. J. Biol. Chem. 267, 19896.
          Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
          Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
          Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
          Krieg, U.C., et al. 1987. Biochemistry 26, 103.
          Product Information
          CAS number9001-24-5
          FormLiquid
          FormulationIn 50% glycerol/H₂O (v/v).
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥20 units/mg protein (clotting assay). Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219365

          References

          Reference overview
          Walker, F.J. 1992. J. Biol. Chem. 267, 19896.
          Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
          Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
          Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
          Krieg, U.C., et al. 1987. Biochemistry 26, 103.

          Brochure

          Title
          Coagulation Factors Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          SynonymsProaccelerin, Labile Factor, Ac-globulin, Ac-g
          DescriptionNative coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca2+, and membrane phospholipids are cofactors which form a "prothrombinase" complex with Factor Xa, enabling its proteolytic activation of prothrombin to thrombin.
          FormLiquid
          FormulationIn 50% glycerol/H₂O (v/v).
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9001-24-5
          Purity≥95% by SDS-PAGE
          Specific activity≥20 units/mg protein (clotting assay). Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.
          Toxicity Standard Handling
          Merck USA index14, 3919
          ReferencesWalker, F.J. 1992. J. Biol. Chem. 267, 19896.
          Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
          Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
          Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
          Krieg, U.C., et al. 1987. Biochemistry 26, 103.