233155 | Cleland’s Reagent - CAS 3483-12-3 - Calbiochem

233155
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₁₀O₂S₂ 3483-12-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233155-100GM
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          Glass bottle 100 gm
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          233155-10GM
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              Plastic ampoule 10 gm
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              233155-1GM
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                  Plastic ampoule 1 gm
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                  233155-1KG
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                      Glass bottle 1 kg
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                      233155-25GM
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                          Glass bottle 25 gm
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                          233155-500GM
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                              Glass bottle 500 gm
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                              233155-5GM
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                                  Plastic ampoule 5 gm
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                                  Description
                                  OverviewA protective agent for SH groups. Cyclizes as it reduces disulfides to thiols, so reaction is "driven" to completion. Does not contain waxy surfactant found in many other preparations.
                                  Oxidized dithiothreitol: ≤0.5%.
                                  Catalogue Number233155
                                  Brand Family Calbiochem®
                                  SynonymsDTT, Dithiothreitol
                                  References
                                  ReferencesGailis, L. 1994. Eur. J. Pharmacol. 292, 39.
                                  Lauriault, V.V.M., and O'Brien, P.J. 1991. Mol. Pharmacol. 40, 125.
                                  Klonne, D.R., and Johnson, D.R. 1988. Toxicol. Lett. 42, 199.
                                  Zahler, W.L., and Cleland, W.W. 1968. J. Biol. Chem. 243, 716.
                                  Cleland, W.W. 1964. Biochemistry 3, 480.
                                  Product Information
                                  CAS number3483-12-3
                                  FormWhite to off-white powder
                                  Hill FormulaC₄H₁₀O₂S₂
                                  Chemical formulaC₄H₁₀O₂S₂
                                  Applications
                                  Biological Information
                                  Purity≥97% by titration
                                  Physicochemical Information
                                  ContaminantsHeavy metals: ≤1 ppm
                                  Heavy metals<1 ppm
                                  Dimensions
                                  Materials Information
                                  Toxicological Information
                                  Safety Information according to GHS
                                  RTECSEK1610000
                                  Safety Information
                                  R PhraseR: 22-36/38

                                  Harmful if swallowed.
                                  Irritating to eyes and skin.
                                  S PhraseS: 36-26

                                  Wear suitable protective clothing.
                                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                                  Product Usage Statements
                                  Storage and Shipping Information
                                  Ship Code Ambient Temperature Only
                                  Toxicity Harmful
                                  Storage +2°C to +8°C
                                  Do not freeze Ok to freeze
                                  Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                                  Packaging Information
                                  Packaged under inert gas Packaged under inert gas
                                  Transport Information
                                  Supplemental Information
                                  Specifications

                                  Documentation

                                  SDS

                                  Title

                                  Safety Data Sheet (SDS) 

                                  Certificates of Analysis

                                  TitleLot Number
                                  233155

                                  References

                                  Reference overview
                                  Gailis, L. 1994. Eur. J. Pharmacol. 292, 39.
                                  Lauriault, V.V.M., and O'Brien, P.J. 1991. Mol. Pharmacol. 40, 125.
                                  Klonne, D.R., and Johnson, D.R. 1988. Toxicol. Lett. 42, 199.
                                  Zahler, W.L., and Cleland, W.W. 1968. J. Biol. Chem. 243, 716.
                                  Cleland, W.W. 1964. Biochemistry 3, 480.

                                  Brochure

                                  Title
                                  Cleland's Reagent (Dithiothreitol) Technical Bulletin
                                  Data Sheet

                                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                                  Revision29-April-2008 RFH
                                  SynonymsDTT, Dithiothreitol
                                  DescriptionDTT is a water-soluble protective reagent for sulfhydryl groups. It maintains monothiols in the reduced state and reduces disulfides quantitatively. Most widely used for the study of disulfide exchange reactions of protein disulfides. DTT readily permeates cell membranes. Protects protein sulfhydryls and restores enzyme activity lost by the oxidation of sulfhydryl groups in vitro. As a reducing agent, it cyclizes as it reduces disulfides to thiols, so the reaction is "driven" to completion without using large excesses of reductant. If free thiols are to be assayed later, excess reductant must be removed by dialysis or some other appropriate method. Alternatively, an immobilized form of DTT (REDUCTACRYL Reagent, Cat. No. 233157) can be used. Oxidized dithiothreitol: ≤0.5%.
                                  FormWhite to off-white powder
                                  Intert gas (Yes/No) Packaged under inert gas
                                  CAS number3483-12-3
                                  RTECSEK1610000
                                  Chemical formulaC₄H₁₀O₂S₂
                                  Purity≥97% by titration
                                  ContaminantsHeavy metals: ≤1 ppm
                                  SolubilityEthanol or H₂O (30 mg/ml)
                                  Storage +2°C to +8°C
                                  Do Not Freeze Ok to freeze
                                  Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                                  Toxicity Harmful
                                  Merck USA index14, 3376
                                  ReferencesGailis, L. 1994. Eur. J. Pharmacol. 292, 39.
                                  Lauriault, V.V.M., and O'Brien, P.J. 1991. Mol. Pharmacol. 40, 125.
                                  Klonne, D.R., and Johnson, D.R. 1988. Toxicol. Lett. 42, 199.
                                  Zahler, W.L., and Cleland, W.W. 1968. J. Biol. Chem. 243, 716.
                                  Cleland, W.W. 1964. Biochemistry 3, 480.