220285 | Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

220285
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₈NO₄Cl 3895-92-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      220285-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewNaturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
          Catalogue Number220285
          Brand Family Calbiochem®
          References
          ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Barg, J., et al. 1992. J. Neurochem. 59, 1145.
          Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
          Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
          Walterova, D., et al. J. Med. Chem. 24, 1100.
          Product Information
          CAS number3895-92-9
          ATP CompetitiveN
          FormLight yellow to yellow solid
          Hill FormulaC₂₁H₁₈NO₄Cl
          Chemical formulaC₂₁H₁₈NO₄Cl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>660 nM
          Purity≥97% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSFL9200000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          220285

          References

          Reference overview
          Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Barg, J., et al. 1992. J. Neurochem. 59, 1145.
          Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
          Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
          Walterova, D., et al. J. Med. Chem. 24, 1100.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionNaturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
          FormLight yellow to yellow solid
          CAS number3895-92-9
          RTECSFL9200000
          Chemical formulaC₂₁H₁₈NO₄Cl
          Structure formulaStructure formula
          Purity≥97% by NMR
          SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml). Heating to 40-50°C with gentle agitation may be necessary to achieve complete solubilization. Further dilute with buffer just prior to use.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful
          Merck USA index14, 2051
          ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Barg, J., et al. 1992. J. Neurochem. 59, 1145.
          Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
          Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
          Walterova, D., et al. J. Med. Chem. 24, 1100.