219489 | Ceramide Kinase Inhibitor, K1

219489
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₈O₄ 1258005-85-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219489-1MG
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          Plastic ampoule 1 mg
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          Description
          Overview

          This product has been discontinued.



          A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 > 100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

          Catalogue Number219489
          Brand Family Calbiochem®
          SynonymsF-12509A Cyclic Product K1
          References
          ReferencesKim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
          Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
          Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
          Product Information
          CAS number1258005-85-4
          DeclarationSold for research purposes only, pursuant to an agreement with Merck Japan.
          FormYellow powder
          Hill FormulaC₂₁H₂₈O₄
          Chemical formulaC₂₁H₂₈O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by NMR (mixture of enantiomers)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219489

          References

          Reference overview
          Kim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
          Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
          Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsF-12509A Cyclic Product K1
          DescriptionA cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1258005-85-4
          Chemical formulaC₂₁H₂₈O₄
          Structure formulaStructure formula
          Purity≥95% by NMR (mixture of enantiomers)
          SolubilityEthanol (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
          Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
          Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.