219503 Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem

219503
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₈IN₃O₄ 943746-57-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219503-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in rat liver microsomes stability assays) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting Cdk4/D1 inhibitor (IC50 = 30 nM) and an effective antiproliferative agent against HCT116 and MCF-7 cancer cells (IC50 = 0.73 and 0.88 µM, respectively), affecting Cdk2/E and Cdk1/B only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
          Catalogue Number219503
          Brand Family Calbiochem®
          Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
          References
          ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
          Product Information
          CAS number943746-57-4
          FormCaramel powder
          Hill FormulaC₁₉H₁₈IN₃O₄
          Chemical formulaC₁₉H₁₈IN₃O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2012 JSW
          Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
          DescriptionA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in the presence of rat liver microsomes, NADPH, and UDPGA) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting inhibitor against Cdk4/D1 kinase activity (IC50 = 30 nM in cell-free Rb c-terminal fragment phosphorylation assays) and an effective antiproliferative agent against HCT116 colorectal and MCF-7 breast cancer cultures (IC50 = 0.73 and 0.88 µM, respectively), while affecting Cdk2/E and Cdk1/B kinase activities only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
          FormCaramel powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number943746-57-4
          Chemical formulaC₁₉H₁₈IN₃O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Regulatory Review
          ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.