238803 | Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

238803
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₈N₆O₃ 199986-75-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      238803-1MG
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          Plastic ampoule 1 mg
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          238803-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
              Catalogue Number238803
              Brand Family Calbiochem®
              Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
              References
              ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
              Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
              Product Information
              CAS number199986-75-9
              ATP CompetitiveY
              DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
              FormWhite solid
              Hill FormulaC₂₀H₂₈N₆O₃
              Chemical formulaC₂₀H₂₈N₆O₃
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetCdk2/A, Cdk2/E
              Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              238803

              References

              Reference overview
              Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
              Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision27-November-2008 RFH
              Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
              DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number199986-75-9
              Chemical formulaC₂₀H₂₈N₆O₃
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (10 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
              Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.