219457 | Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

219457
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₄N₆O₂ 471270-60-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219457-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.
          Catalogue Number219457
          Brand Family Calbiochem®
          Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
          References
          ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.
          Product Information
          CAS number471270-60-7
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₈H₂₄N₆O₂
          Chemical formulaC₁₈H₂₄N₆O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCDK1, CDK2
          Primary Target IC<sub>50</sub>100 nM, 80 nM, against Cdk1 and Cdk2, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219457

          References

          Reference overview
          Vermeulen, K., et al. 2002. Leukemia 16, 299.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
          DescriptionAn analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number471270-60-7
          Chemical formulaC₁₈H₂₄N₆O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.