219555 Cathepsin K Substrate II, Fluorogenic - Calbiochem

219555
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219555-1MG
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      Stocked 
      Discontinued
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          Plastic ampoule 1 mg
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          Description
          OverviewAn internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.
          Catalogue Number219555
          Brand Family Calbiochem®
          SynonymsAbz-HPG~GPQ-EDN₂ph
          References
          ReferencesLecaille, F., et al. 2003. Biochem. J. 375, 307.
          Product Information
          FormBright yellow solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₄₀H₅₀N₁₄O₁₂
          Chemical formulaC₄₀H₅₀N₁₄O₁₂
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Emission max.
          Excitation max.
          Peptide SequenceAbz-His-Pro-Gly~Gly-Pro-Gln-EDDnp
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219555

          References

          Reference overview
          Lecaille, F., et al. 2003. Biochem. J. 375, 307.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-August-2009 RFH
          SynonymsAbz-HPG~GPQ-EDN₂ph
          DescriptionAn internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.
          FormBright yellow solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₀H₅₀N₁₄O₁₂
          Peptide SequenceAbz-His-Pro-Gly~Gly-Pro-Gln-EDDnp
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLecaille, F., et al. 2003. Biochem. J. 375, 307.