218775 | Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem

218775
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₅NO₄ 79831-76-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218775-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewPlant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9(GlcNAc)2. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.
          Catalogue Number218775
          Brand Family Calbiochem®
          Synonyms(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine
          References
          ReferencesAhmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
          Pili, R., et al. 1995. Cancer Res. 55, 2920.
          Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
          Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
          Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.
          Product Information
          CAS number79831-76-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₁₅NO₄
          Chemical formulaC₈H₁₅NO₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetβ-glucosidases
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218775

          References

          Reference overview
          Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
          Pili, R., et al. 1995. Cancer Res. 55, 2920.
          Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
          Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
          Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.

          Citations

          Title
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-August-2010 JSW
          Synonyms(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine
          DescriptionPlant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9 (GlcNAc)2. Inhibits endothelial cell angiogenesis and tumor growth. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number79831-76-8
          Chemical formulaC₈H₁₅NO₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 1896
          ReferencesAhmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
          Pili, R., et al. 1995. Cancer Res. 55, 2920.
          Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
          Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
          Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.
          Citation
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.