218765 Caspase-9 Substrate I, Fluorogenic - Calbiochem

218765
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218765-1MG
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          Glass bottle 1 mg
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          218765-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
              Catalogue Number218765
              Brand Family Calbiochem®
              SynonymsAc-LEHD-AFC
              References
              ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
              Product Information
              ATP CompetitiveN
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₃₃H₃₈F₃N₇O₁₁
              Chemical formulaC₃₃H₃₈F₃N₇O₁₁
              ReversibleN
              Applications
              Biological Information
              Primary TargetA fluorogenic substrate for caspase-9
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Emission max.
              Excitation max.
              Peptide SequenceAc-Leu-Glu-His-Asp-AFC
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              218765

              References

              Reference overview
              Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision04-June-2008 RFH
              SynonymsAc-LEHD-AFC
              DescriptionA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Chemical formulaC₃₃H₃₈F₃N₇O₁₁
              Peptide SequenceAc-Leu-Glu-His-Asp-AFC
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from moisture
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.