218833 Caspase-6 Inhibitor XII, pep419 - Calbiochem

218833
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉₉H₁₆₂N₃₀O₂₉S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218833-5MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 5 mg
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          Description
          OverviewAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
          Catalogue Number218833
          Brand Family Calbiochem®
          SynonymsCaspase inhibitor, pep419
          References
          ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
          Product Information
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₉H₁₆₂N₃₀O₂₉S
          Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218833

          References

          Reference overview
          Stanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-June-2013 JSW
          SynonymsCaspase inhibitor, pep419
          DescriptionAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
          Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
          Purity≥95% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.