218750 | Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem

218750
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₃₁ClN₄O₁₁ 285570-60-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218750-1MG
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          Plastic ampoule 1 mg
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          218750-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.
              Catalogue Number218750
              Brand Family Calbiochem®
              SynonymsAc-DEVD-CMK
              References
              ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
              Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Product Information
              CAS number285570-60-7
              ATP CompetitiveN
              FormWhite to off-white lyophilized solid or powder
              Hill FormulaC₂₁H₃₁ClN₄O₁₁
              Chemical formulaC₂₁H₃₁ClN₄O₁₁
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              218750

              References

              Reference overview
              Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
              Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

              Citations

              Title
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision09-April-2018 JSW
              SynonymsAc-DEVD-CMK
              DescriptionA potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
              FormWhite to off-white lyophilized solid or powder
              CAS number285570-60-7
              Chemical formulaC₂₁H₃₁ClN₄O₁₁
              Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
              Structure formulaStructure formula
              Purity≥98% by HPLC
              Solubility20% Acetonitrile (in H₂O) (1 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Toxicity Standard Handling
              ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
              Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Citation
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.