400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

400015
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₃H₄₂N₄O₁₀ 154674-81-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400015-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
          Catalogue Number400015
          Brand Family Calbiochem®
          SynonymsICE Inhibitor IV, Ac-YVAD-AOM
          References
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
          Product Information
          CAS number154674-81-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₃H₄₂N₄O₁₀
          Chemical formulaC₃₃H₄₂N₄O₁₀
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcaspase-1
          Purity≥96% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400015

          References

          Reference overview
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2011 RFH
          SynonymsICE Inhibitor IV, Ac-YVAD-AOM
          DescriptionHighly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
          FormWhite solid
          CAS number154674-81-4
          Chemical formulaC₃₃H₄₂N₄O₁₀
          Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
          Structure formulaStructure formula
          Purity≥96% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors