218697 | Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem

218697
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆HBr₄N₃ 17374-26-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218697-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
          Catalogue Number218697
          Brand Family Calbiochem®
          SynonymsTBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
          References
          ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
          Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
          Sarno, S., et al. 2001. FEBS Lett. 496, 44.
          Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
          Product Information
          CAS number17374-26-4
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₆HBr₄N₃
          Chemical formulaC₆HBr₄N₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCasein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2).
          Biological Information
          Primary TargetCK2 rat liver, human recombinant
          Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; < 1 µM for DYRK1a
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218697

          References

          Reference overview
          Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
          Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
          Sarno, S., et al. 2001. FEBS Lett. 496, 44.
          Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-January-2009 JSW
          SynonymsTBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
          DescriptionA cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number17374-26-4
          Chemical formulaC₆HBr₄N₃
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
          Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
          Sarno, S., et al. 2001. FEBS Lett. 496, 44.
          Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.