217386 | Carboxy-PTIO, Sodium Salt - Calbiochem

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Carboxy-PTIO, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na

217386
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₆N₂O₄ · Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      217386-10MG
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          		Plastic ampoule 10 mg
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          Description
          OverviewReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
          Catalogue Number217386
          Brand Family Calbiochem®
          Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
          References
          ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
          Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
          Hogg, N., et al. 1995. Free Radical Res. 22, 47.
          Az-ma, T., et al. 1994. Life Sci. 54, 185.
          Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
          Akaike, T., et al. 1993. Biochemistry 32, 827.
          Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.
          Product Information
          ATP CompetitiveN
          FormDark blue solid
          Hill FormulaC₁₄H₁₆N₂O₄ · Na
          Chemical formulaC₁₄H₁₆N₂O₄ · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNitric oxide scavenging action
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          217386

          References

          Reference overview
          Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
          Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
          Hogg, N., et al. 1995. Free Radical Res. 22, 47.
          Az-ma, T., et al. 1994. Life Sci. 54, 185.
          Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
          Akaike, T., et al. 1993. Biochemistry 32, 827.
          Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-June-2008 RFH
          Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
          DescriptionReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
          FormDark blue solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₁₆N₂O₄ · Na
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityHEPES Buffer (0.4 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
          Toxicity Standard Handling
          ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
          Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
          Hogg, N., et al. 1995. Free Radical Res. 22, 47.
          Az-ma, T., et al. 1994. Life Sci. 54, 185.
          Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
          Akaike, T., et al. 1993. Biochemistry 32, 827.
          Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.