211280 | Capsazepine - CAS 138977-28-3 - Calbiochem

211280
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₁N₂O₂SCl 138977-28-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      211280-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
          Catalogue Number211280
          Brand Family Calbiochem®
          SynonymsN-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
          References
          ReferencesFox, A.J., et al. 1995. Neuroscience 67, 741.
          Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
          Walpole, C.S.J., et al. 1994. J. Med. Chem. 37, 1942.
          Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap. 267, 728.
          Product Information
          CAS number138977-28-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₉H₂₁N₂O₂SCl
          Chemical formulaC₁₉H₂₁N₂O₂SCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA competitive antagonist of Capsaicin and resiniferatoxin
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          211280

          References

          Reference overview
          Fox, A.J., et al. 1995. Neuroscience 67, 741.
          Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
          Walpole, C.S.J., et al. 1994. J. Med. Chem. 37, 1942.
          Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap. 267, 728.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-November 2016 JSW
          SynonymsN-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
          DescriptionA competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
          FormOff-white solid
          CAS number138977-28-3
          Chemical formulaC₁₉H₂₁N₂O₂SCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO or Methanol
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesFox, A.J., et al. 1995. Neuroscience 67, 741.
          Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
          Walpole, C.S.J., et al. 1994. J. Med. Chem. 37, 1942.
          Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap. 267, 728.