420175 | Cancer Hydrolase KIAA1363 Inhibitor, JW480 - CAS 1354359-53-7 - Calbiochem

420175
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₃NO₂ 1354359-53-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420175-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50 = 12 nM; PC3 lysate) and murine (IC50 = 20 nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80 mg/kg/day; o.g.). Also inhibits blood carboxylesterase.
          Catalogue Number420175
          Brand Family Calbiochem®
          SynonymsAADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor, 2ʹ-Isopropylphenyl-2-(2-naphthyl)ethylcarbamate
          References
          ReferencesChang, J.W., et al. 2011. Chem. Biol. 18, 476.
          Product Information
          CAS number1354359-53-7
          FormWhite powder
          Hill FormulaC₂₂H₂₃NO₂
          Chemical formulaC₂₂H₂₃NO₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420175

          References

          Reference overview
          Chang, J.W., et al. 2011. Chem. Biol. 18, 476.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-June-2012 JSW
          SynonymsAADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor, 2ʹ-Isopropylphenyl-2-(2-naphthyl)ethylcarbamate
          DescriptionA membrane-permeable carbamate that acts as a highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50 = 12 nM; PC3 cell lysate) and murine (IC50 = 20 nM; mouse brain membrane homogenate) origin, presumably via covalent/irreversible carbamoylation of enzyme active site nucleophilic serine, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice (complete inhibition of brain KIAA1363 in 4 h after single i.p. or o.g./oral gavage dose of 5 mg/kg and 20 mg/kg, respectively). Reported to inhibit the survival of PC3 prostate cancer cells in cultures in vitro (by 34%; 48 h; 1 µM) and suppress PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80 mg/kg/day; o.g.). Also inhibits blood carboxylesterase.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1354359-53-7
          Chemical formulaC₂₂H₂₃NO₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml; clear, colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesChang, J.W., et al. 2011. Chem. Biol. 18, 476.