208925 | Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

208925
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₆N₂O₄ 7689-03-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208925-50MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Alu drum 50 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G2/M phase.
          Catalogue Number208925
          Brand Family Calbiochem®
          Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
          References
          ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
          Product Information
          CAS number7689-03-4
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₂₀H₁₆N₂O₄
          Chemical formulaC₂₀H₁₆N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA topoisomerase 1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUQ0492000
          Safety Information
          R PhraseR: 25-36/37/38-46

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause heritable genetic damage.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208925

          References

          Reference overview
          Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-July-2009 RFH
          Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
          DescriptionA cell-permeable, reversible DNA topoisomerase I inhibitor that binds to and stabilizes the topoisomerase-DNA covalent complex. Possesses antileukemic and antitumor properties. Inhibits Tat-mediated transactivation of HIV-1. Cytostatic for non-tumorigenic cells but cytotoxic for tumorigenic cells. Induces apoptosis of HL-60 cells and mouse thymocytes.
          FormPale yellow solid
          CAS number7689-03-4
          RTECSUQ0492000
          Chemical formulaC₂₀H₁₆N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) and MeOH (40 mg/ml). Stock solutions made with methanol will remain cloudy.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 1735
          ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.