208745 | Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

208745
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₅FN₂O₄S 190274-53-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208745-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          208745-5MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service

              Plastic ampoule 5 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
              Catalogue Number208745
              Brand Family Calbiochem®
              SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
              References
              ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
              Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
              Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
              Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
              Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
              Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
              Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
              Product Information
              CAS number190274-53-4
              ATP CompetitiveN
              DeclarationSold under license of U.S. Patent 6,551,999
              FormWhite lyophilized solid
              Hill FormulaC₁₇H₂₅FN₂O₄S
              Chemical formulaC₁₇H₂₅FN₂O₄S
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetµ-calpain
              Primary Target IC<sub>50</sub>7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              208745

              References

              Reference overview
              Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
              Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
              Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
              Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
              Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
              Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
              Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-February-2014 JSW
              SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
              DescriptionA cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and cathepsin L (IC50 = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
              FormWhite lyophilized solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number190274-53-4
              Chemical formulaC₁₇H₂₅FN₂O₄S
              Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
              Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
              Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
              Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
              Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
              Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
              Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.