208772 | Calpain-1 Substrate II, Fluorogenic - Calbiochem

208772
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208772-1MG
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      Stocked 
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          Glass bottle 1 mg
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          Description
          OverviewAn internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides. Shown to be kinetically superior, in terms of turnover rate, to Calpain Substrate III, Fluorogenic (Cat. No. 208771), Calpain-1 Substrate, Fluorogenic (Cat. No. 208748), and Calpain Substrate II, Fluorogenic (Cat. No. 208731) by ~8-, 18-, and 310-fold, respectively.
          Catalogue Number208772
          Brand Family Calbiochem®
          SynonymsH-E(EDANS)PLF~AERK(DABCYL)-OH
          References
          ReferencesCuerrier, D., et al. 2007. J. Biol. Chem. 282, 9600.
          Cuerrier, D., et al. 2005. J. Biol. Chem. 280, 40632.
          Product Information
          ATP CompetitiveN
          FormRed lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₂H₉₇N₁₇O₁₆S
          Chemical formulaC₇₂H₉₇N₁₇O₁₆S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetCalpain-1 Substrate
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceH₂N-Glu(EDANS)-Pro-Leu-Phe~Ala-Glu-Arg-Lys(DABCYL)-CO₂H
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208772

          References

          Reference overview
          Cuerrier, D., et al. 2007. J. Biol. Chem. 282, 9600.
          Cuerrier, D., et al. 2005. J. Biol. Chem. 280, 40632.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-January-2008 JSW
          SynonymsH-E(EDANS)PLF~AERK(DABCYL)-OH
          DescriptionAn internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides. Shown to be kinetically superior, in terms of turnover rate, to Calpain Substrate III, Fluorogenic (Cat. No. 208771), Calpain-1 Substrate, Fluorogenic (Cat. No. 208748), and Calpain Substrate II, Fluorogenic (Cat. No. 208731) by ~8-, 18-, and 310-fold, respectively. Excitation: ~335 nm; emission: ~505 nm.
          FormRed lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₇₂H₉₇N₁₇O₁₆S
          Peptide SequenceH₂N-Glu(EDANS)-Pro-Leu-Phe~Ala-Glu-Arg-Lys(DABCYL)-CO₂H
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesCuerrier, D., et al. 2007. J. Biol. Chem. 282, 9600.
          Cuerrier, D., et al. 2005. J. Biol. Chem. 280, 40632.