208713 | Calpain-1, Human Erythrocytes

208713
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208713-500UG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 500 μg
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          Description
          OverviewNative calpain-1 from human erythrocytes. Ca2+-dependent heterodimeric cysteine proteinase with low Ca2+ requirement (EC50= 2 µM).
          Catalogue Number208713
          Brand Family Calbiochem®
          Synonymsμ-Calpain
          References
          ReferencesVanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
          Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
          Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 pmol Suc-LLVY-AMC in 1 min, 25°C using the Calpain Activity Assay Kit, Fluorogenic (Cat. No. QIA120). Note: 1 caseinolytic unit = 1 fluorogenic unit.
          EC number3.4.22.17
          FormLiquid
          FormulationIn 20 mM imidazole, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
          Applications
          Biological Information
          PurityComparable to reference lot by SDS-PAGE
          SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥1000 units/mg protein
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38-42/43

          Irritating to eyes, respiratory system and skin.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208713

          References

          Reference overview
          Vanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
          Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
          Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Proteases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-January-2009 JSW
          Synonymsμ-Calpain
          DescriptionNative calpain-1 from human erythrocytes. Ca2+-dependent cysteine proteinase with low Ca2+ requirement (half-maximal activation = 2 µM). Participates in the ATP release reaction of platelets stimulated with thrombin.
          FormLiquid
          FormulationIn 20 mM imidazole, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          EC number3.4.22.17
          PurityComparable to reference lot by SDS-PAGE
          Specific activity≥1000 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1 pmol Suc-LLVY-AMC in 1 min, 25°C using the Calpain Activity Assay Kit, Fluorogenic (Cat. No. QIA120). Note: 1 caseinolytic unit = 1 fluorogenic unit.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Harmful
          ReferencesVanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
          Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
          Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.

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          Categories

          Life Science Research > Proteins and Enzymes > Other Enzymes