208923 | CaMKII Inhibitor XII - Calbiochem

208923
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208923-5MG
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      Stocked 
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          Glass bottle 5 mg
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          Description
          OverviewA pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).
          Catalogue Number208923
          Brand Family Calbiochem®
          SynonymsCa2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII
          References
          ReferencesAsano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.
          Product Information
          FormWhite powder
          Hill FormulaC₂₉H₃₀ClN₅O₂S
          Chemical formulaC₂₉H₃₀ClN₅O₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Asano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-August-2013 JSW
          SynonymsCa2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII
          DescriptionA pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₉H₃₀ClN₅O₂S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAsano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.