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|208923-5MG||Glass bottle||5 mg||
|Overview||A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).|
|Synonyms||Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII|
|References||Asano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.|
|Structure formula Image|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Asano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.|
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