239819 CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem

239819
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₁N₃O₄ 473728-67-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239819-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
          Catalogue Number239819
          Brand Family Calbiochem®
          Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
          Application Data
          References
          ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.
          Product Information
          CAS number473728-67-5
          FormOff-white solid
          Hill FormulaC₁₈H₂₁N₃O₄
          Chemical formulaC₁₈H₂₁N₃O₄
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239819

          References

          Reference overview
          Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
          Application Data
          DescriptionA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number473728-67-5
          Chemical formulaC₁₈H₂₁N₃O₄
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml; light brown solution)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.