504914 | CNQX - CAS 115066-14-3 - Calbiochem

504914
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₄N₄O₄ 115066-14-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04914.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent and competitive antagonist for AMPA/kainate receptors (Ki = 0.6 - 2.11 µM for GluA1-4 and Ki = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number504914
          Brand Family Calbiochem®
          Synonyms6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
          References
          ReferencesLee, S., et al. 2010. J. Neurophysiol. 103, 1728.
          King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
          Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.
          Product Information
          CAS number115066-14-3
          FormOff-white to yellow solid
          Hill FormulaC₉H₄N₄O₄
          Chemical formulaC₉H₄N₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAMPA
          Primary Target K<sub>i</sub>0.6 – 2.11 →M for GluA1 – 4 and Ki
          Secondary targetKainate
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lee, S., et al. 2010. J. Neurophysiol. 103, 1728.
          King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
          Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2016 JSW
          Synonyms6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
          DescriptionA potent and competitive antagonist for AMPA/kainate receptors (Ki = 0.6 - 2.11 µM for GluA1-4 and Ki = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.
          FormOff-white to yellow solid
          CAS number115066-14-3
          Chemical formulaC₉H₄N₄O₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, S., et al. 2010. J. Neurophysiol. 103, 1728.
          King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
          Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.