233100 CL-387,785 - CAS 194423-06-8 - Calbiochem

233100
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₃BrN₄O 194423-06-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233100-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR.
          Catalogue Number233100
          Brand Family Calbiochem®
          SynonymsN-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
          References
          ReferencesSweeney, W.E., et al. 2000. Kidney Int. 57, 33.
          Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
          Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.
          Product Information
          CAS number194423-06-8
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₈H₁₃BrN₄O
          Chemical formulaC₁₈H₁₃BrN₄O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGFR kinase activity
          Primary Target IC<sub>50</sub>250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in vivo; 5 nM inhibiting EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233100

          References

          Reference overview
          Sweeney, W.E., et al. 2000. Kidney Int. 57, 33.
          Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
          Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          SynonymsN-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
          DescriptionA cell-permeable and irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50 = 250-490 pM) and blocks EGF-mediated growth. Also inhibits proliferation of cells that overexpress EGFR or c-Erb-2 (IC50 = 31-125 nM) by covalently binding to EGFR.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number194423-06-8
          Chemical formulaC₁₈H₁₃BrN₄O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesSweeney, W.E., et al. 2000. Kidney Int. 57, 33.
          Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
          Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.