220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

220201
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₅₈N₂O₇S 75621-03-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      220201-10GM
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          Plastic ampoule 10 gm
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          220201-1GM
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              Glass bottle 1 gm
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              220201-1KG
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                  Glass bottle 1 kg
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                  220201-250GM
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                      Glass bottle 250 gm
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                      220201-25GM
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                          Glass bottle 25 gm
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                          220201-5GM
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                              Plastic ampoule 5 gm
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                              Description
                              OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
                              Conductivity (1.0 M, 24°C): <100 µmhos.
                              Catalogue Number220201
                              Brand Family Calbiochem®
                              Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                              References
                              ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                              Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                              Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                              Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                              Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                              Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                              Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
                              Product Information
                              CAS number75621-03-3
                              Aggregation Number4 - 14
                              CMC6 - 10 mM
                              FormWhite crystalline powder
                              Hill FormulaC₃₂H₅₈N₂O₇S
                              Chemical formulaC₃₂H₅₈N₂O₇S
                              Hygroscopic Hygroscopic
                              Micellar weight6150
                              Applications
                              Biological Information
                              Purity≥98% by NMR
                              Physicochemical Information
                              ContaminantsDNase, RNase, and Protease: none detected
                              Dimensions
                              Materials Information
                              Toxicological Information
                              Safety Information according to GHS
                              Safety Information
                              R PhraseR: 22-36/38

                              Harmful if swallowed.
                              Irritating to eyes and skin.
                              S PhraseS: 26-36

                              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                              Wear suitable protective clothing.
                              Product Usage Statements
                              Storage and Shipping Information
                              Ship Code Ambient Temperature Only
                              Toxicity Harmful
                              Storage +15°C to +30°C
                              Hygroscopic Hygroscopic
                              Do not freeze Ok to freeze
                              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                              Packaging Information
                              Transport Information
                              Supplemental Information
                              Specifications

                              Documentation

                              SDS

                              Title

                              Safety Data Sheet (SDS) 

                              Certificates of Analysis

                              TitleLot Number
                              220201

                              References

                              Reference overview
                              Chen, Y., et al. 1992. Biochemistry 31, 2415.
                              Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                              Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                              Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                              Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                              Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                              Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

                              Brochure

                              Title
                              CALBIOSORBル Technical Bulletin
                              Detergents and Buffers Technical Bulletin
                              Data Sheet

                              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                              Revision12-November-2010 RFH
                              Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                              DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
                              FormWhite crystalline powder
                              CAS number75621-03-3
                              Chemical formulaC₃₂H₅₈N₂O₇S
                              Purity≥98% by NMR
                              ContaminantsDNase, RNase, and Protease: none detected
                              SolubilityH₂O (1.0 M)
                              Storage +15°C to +30°C
                              Hygroscopic
                              Do Not Freeze Ok to freeze
                              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                              Toxicity Harmful
                              Merck USA index14, 2044
                              ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                              Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                              Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                              Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                              Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                              Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                              Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.