220005 | CGP-37157 - CAS 75450-34-9 - Calbiochem

220005
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₁Cl₂NOS 75450-34-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      220005-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
          Catalogue Number220005
          Brand Family Calbiochem®
          Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
          References
          ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
          Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
          Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
          Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
          White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
          Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
          Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
          Product Information
          CAS number75450-34-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₁₁Cl₂NOS
          Chemical formulaC₁₅H₁₁Cl₂NOS
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMitochondrial Na+/Ca2+ exchanger
          Primary Target IC<sub>50</sub>360 nM against mitochondrial Na+/Ca2+ exchanger
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          220005

          References

          Reference overview
          Jornot, L., et al. 1999. J. Cell Sci. 112, 1013.
          Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
          Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
          Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
          White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
          Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
          Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2013 JSW
          Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
          DescriptionA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number75450-34-9
          Chemical formulaC₁₅H₁₁Cl₂NOS
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml). Dilute in Ca2+-free buffer just prior to use.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
          Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
          Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
          Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
          White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
          Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
          Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.