203987 | Butein - CAS 487-52-5 - Calbiochem

203987
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂O₅ 487-52-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203987-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
          Catalogue Number203987
          Brand Family Calbiochem®
          Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
          References
          ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
          Chan, S.C., et al. 1998. Planta Med. 64, 153.
          Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
          Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
          Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
          Product Information
          CAS number487-52-5
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₅H₁₂O₅
          Chemical formulaC₁₅H₁₂O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTyrosine kinase activity of the EGF receptor
          Primary Target IC<sub>50</sub>65 µM against tyrosine kinase activity of the EGF receptor
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203987

          References

          Reference overview
          Howitz, K.T., et al. 2003. Nature 425, 191.
          Chan, S.C., et al. 1998. Planta Med. 64, 153.
          Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
          Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
          Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
          DescriptionA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM) The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase (GSH-RD) and rat liver glutathione S-transferase (GST; IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number487-52-5
          Chemical formulaC₁₅H₁₂O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
          Chan, S.C., et al. 1998. Planta Med. 64, 153.
          Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
          Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
          Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.