506239 | Bupropion Hydrochloride - CAS 31677-93-7 - Calbiochem

506239
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₈ClNO·HCl 31677-93-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06239.0001
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          Glass bottle 50 mg
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          Description
          OverviewA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
          Catalogue Number506239
          Brand Family Calbiochem®
          SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
          References
          ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
          Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
          Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
          Product Information
          CAS number31677-93-7
          FormWhite solid
          Hill FormulaC₁₃H₁₈ClNO·HCl
          Chemical formulaC₁₃H₁₈ClNO·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDAT/NET
          Primary Target K<sub>i</sub>1.4 µ
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 46

          If swallowed, seek medical advice immediately and show this container or label.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Budzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
          Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
          Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
          DescriptionA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
          FormWhite solid
          CAS number31677-93-7
          Chemical formulaC₁₃H₁₈ClNO·HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
          Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
          Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.