203350 Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem

203350
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₆N₈O5 · HCl 3513-03-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203350-25MG
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          Glass bottle 25 mg
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          Description
          OverviewNucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for use as a dominant selectable marker in conjunction with blasticidin S resistant plasmids. Blasticidin S resistance is conferred by the blasticidin S deaminase gene (bcr), which converts blastisidin S to a nontoxic deaminohydroxy derivative.
          Catalogue Number203350
          Brand Family Calbiochem®
          References
          ReferencesKimura, M., et al. 1994. Biochim. Biophys. Acta 1219, 653.
          Kimura, M., et al. 1994, Mol. Gen. Genet. 242, 121.
          Kojima, N., et al. 1994. J. Biol. Chem. 269, 30451.
          Kudo, T., et al. 1994. J. Immunol. Methods 177, 17.
          Sutoh, K. 1993. Plasmid 30, 150.
          Izumi, M., et al. 1991. Exp. Cell Res. 197, 229.
          Yamaguchi, H., et al. 1965. J. Biol. Chem. 57, 667.
          Takeuchi, S., et al. 1958. J. Antibiot. 11, 1.
          Product Information
          CAS number3513-03-9
          FormWhite solid
          Hill FormulaC₁₇H₂₆N₈O5 · HCl
          Chemical formulaC₁₇H₂₆N₈O5 · HCl
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein synthesis
          Purity≥ 98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 28

          Very toxic if swallowed.
          S PhraseS: 24/25-36/37-45

          Avoid contact with skin and eyes.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions (pH ≤7) are stable for up to 1 year at -20°C. Avoid alkaline pH. Do not subject to freeze/thaw cycles; upon thawing any aliquots, discard the unused portion.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203350

          References

          Reference overview
          Kimura, M., et al. 1994. Biochim. Biophys. Acta 1219, 653.
          Kimura, M., et al. 1994, Mol. Gen. Genet. 242, 121.
          Kojima, N., et al. 1994. J. Biol. Chem. 269, 30451.
          Kudo, T., et al. 1994. J. Immunol. Methods 177, 17.
          Sutoh, K. 1993. Plasmid 30, 150.
          Izumi, M., et al. 1991. Exp. Cell Res. 197, 229.
          Yamaguchi, H., et al. 1965. J. Biol. Chem. 57, 667.
          Takeuchi, S., et al. 1958. J. Antibiot. 11, 1.

          Brochure

          Title
          Drugs for Selection of Genetic Markers Technical Bulletin

          Citations

          Title
        • Richard L Bennett, et al. (2006) RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy and viral infection.. Blood in press,.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionNucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase genes (bsr from Bacillus cereus or BSD from Aspergillus terreus), whose products convert blasticidin S to a non-toxic deaminohydroxy derivative.
          FormWhite solid
          Recommended reaction conditionsTypically used at 2-10 µg/ml for mammalian cell selection.
          CAS number3513-03-9
          Chemical formulaC₁₇H₂₆N₈O5 · HCl
          Structure formulaStructure formula
          Purity≥ 98% by HPLC
          SolubilityH₂O (20 mg/ml) or Dilute Acetic Acid
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions (pH ≤7) are stable for up to 1 year at -20°C. Avoid alkaline pH. Do not subject to freeze/thaw cycles; upon thawing any aliquots, discard the unused portion.
          Toxicity Highly Toxic
          Merck USA index14, 1316
          ReferencesKimura, M., et al. 1994. Biochim. Biophys. Acta 1219, 653.
          Kimura, M., et al. 1994, Mol. Gen. Genet. 242, 121.
          Kojima, N., et al. 1994. J. Biol. Chem. 269, 30451.
          Kudo, T., et al. 1994. J. Immunol. Methods 177, 17.
          Sutoh, K. 1993. Plasmid 30, 150.
          Izumi, M., et al. 1991. Exp. Cell Res. 197, 229.
          Yamaguchi, H., et al. 1965. J. Biol. Chem. 57, 667.
          Takeuchi, S., et al. 1958. J. Antibiot. 11, 1.
          Citation
        • Richard L Bennett, et al. (2006) RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy and viral infection.. Blood in press,.