203297 | Bisindolylmaleimide IV - CAS 119139-23-0 - Calbiochem

203297
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₃N₃O₂ 119139-23-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203297-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).
          Catalogue Number203297
          Brand Family Calbiochem®
          SynonymsArcyriarubin A, 2,3-bis(1H-Indol-3-yl)maleimide, Ro 31-6233
          References
          ReferencesFabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
          Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Product Information
          CAS number119139-23-0
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₂₀H₁₃N₃O₂
          Chemical formulaC₂₀H₁₃N₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>87 nM against protein kinase C
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203297

          References

          Reference overview
          Fabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
          Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-November-2010 JSW
          SynonymsArcyriarubin A, 2,3-bis(1H-Indol-3-yl)maleimide, Ro 31-6233
          DescriptionA cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
          FormOrange solid
          CAS number119139-23-0
          Chemical formulaC₂₀H₁₃N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesFabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
          Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.