201125 | Binucleine 2 - CAS 220088-42-6 - Calbiochem

201125
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₁ClFN₅ 220088-42-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      201125-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyrazolo compound that inhibits cytokinesis function of the Aurora B kinase pathway. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, while inactive in mammalian systems. Does neither function as a general kinase inhibitor nor inhibit Cdk-dependent entry into mitosis.
          Catalogue Number201125
          Brand Family Calbiochem®
          SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
          References
          ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
          Product Information
          CAS number220088-42-6
          FormBrown solid
          Hill FormulaC₁₃H₁₁ClFN₅
          Chemical formulaC₁₃H₁₁ClFN₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          201125

          References

          Reference overview
          Eggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-February-2008 JSW
          SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
          DescriptionA cell-permeable pyrazolo compound that inhibits the cytokinesis function of the Aurora B kinase pathway. Shown to inhibit Aurora β-dependent phosphorylation, but not a general kinase inhibitor. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, but is inactive in mammalian systems. Inhibit Cdk-dependent entry into mitosis.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220088-42-6
          Chemical formulaC₁₃H₁₁ClFN₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.