200484 | Bestatin - CAS 58970-76-6 - Calbiochem

200484
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₄N₂O₄ 58970-76-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      200484-10MG
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          Plastic ampoule 10 mg
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          200484-2GM
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              Glass bottle 2 gm
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              Description
              OverviewBinds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has antitumor properties. Also available as a 50 mM solution in water (Cat. No. 200488).
              Catalogue Number200484
              Brand Family Calbiochem®
              Synonyms[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu
              References
              ReferencesInoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
              Taylor, A., et al. 1993. Biochemistry 32, 784.
              Ishida, J.I., et al. 1984. J. Chromatogr. 305, 381.
              Umezawa, H. 1982. Annu. Rev. Microbiol. 36, 75.
              Product Information
              CAS number58970-76-6
              ATP CompetitiveN
              FormWhite crystalline solid
              Hill FormulaC₁₆H₂₄N₂O₄
              Chemical formulaC₁₆H₂₄N₂O₄
              ReversibleN
              Applications
              ApplicationBestatin, CAS 58970-76-6, is a potent inhibitor of surface aminopeptidases, notably aminopeptidase B, N, and leucine aminopeptidase. Activates macrophages and T lymphocytes.
              Biological Information
              Primary Targetamino peptidase b
              Purity>99% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSOH2915000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO and methanol stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              200484

              References

              Reference overview
              Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
              Taylor, A., et al. 1993. Biochemistry 32, 784.
              Ishida, J.I., et al. 1984. J. Chromatogr. 305, 381.
              Umezawa, H. 1982. Annu. Rev. Microbiol. 36, 75.

              Citations

              Title
            • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision13-May-2013 JSW
              Synonyms[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu
              DescriptionBinds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM.
              FormWhite crystalline solid
              CAS number58970-76-6
              RTECSOH2915000
              Chemical formulaC₁₆H₂₄N₂O₄
              Purity>99% by HPLC
              SolubilityDMSO (2 mg/ml) or Methanol (5 mg/ml). Unstable in aqueous solution; dilute just prior to use.
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO and methanol stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 9842
              ReferencesInoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
              Taylor, A., et al. 1993. Biochemistry 32, 784.
              Ishida, J.I., et al. 1984. J. Chromatogr. 305, 381.
              Umezawa, H. 1982. Annu. Rev. Microbiol. 36, 75.
              Citation
            • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.