203408 BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem

203408
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl 55658-47-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203408-100MG
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          Plastic ampoule 100 mg
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          203408-10MG
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              Plastic ampoule 10 mg
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              203408-250MG
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                  Plastic ampoule 250 mg
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                  Description
                  OverviewA unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ Antibiotic cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
                  Catalogue Number203408
                  Brand Family Calbiochem®
                  References
                  ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
                  Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
                  Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
                  Takita, T., et al. 1972. J. Antibiot. 25, 755.
                  Product Information
                  CAS number55658-47-4
                  FormBlue lyophilized solid
                  Hill FormulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
                  Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
                  Hygroscopic Hygroscopic
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Purity≥85% by HPLC
                  Physicochemical Information
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSEC5990700
                  Safety Information
                  R PhraseR: 20/21/22-36/37/38-40-42/43

                  Harmful by inhalation, in contact with skin and if swallowed.
                  Irritating to eyes, respiratory system and skin.
                  Limited evidence of a carcinogenic effect.
                  May cause sensitization by inhalation and skin contact.
                  S PhraseS: 22-26-36/37/39-45

                  Do not breathe dust.
                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing, gloves and eye/face protection.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful & Carcinogenic / Teratogenic
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  203408

                  References

                  Reference overview
                  Sergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
                  Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
                  Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
                  Takita, T., et al. 1972. J. Antibiot. 25, 755.

                  Brochure

                  Title
                  BLEOCIN Technical Bulletin
                  Drugs for Selection of Genetic Markers Technical Bulletin
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision26-September-2007 RFH
                  DescriptionA unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
                  FormBlue lyophilized solid
                  CAS number55658-47-4
                  RTECSEC5990700
                  Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
                  Structure formulaStructure formula
                  Purity≥85% by HPLC
                  SolubilityH₂O (10 mg/ml)
                  Storage +2°C to +8°C
                  Hygroscopic
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
                  Toxicity Harmful & Carcinogenic / Teratogenic
                  ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
                  Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
                  Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
                  Takita, T., et al. 1972. J. Antibiot. 25, 755.