196418 | BAPTA, Tetrasodium Salt

196418
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₀N₂O₁₀ · 4Na 126824-24-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      196418-1GM
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          Plastic ampoule 1 gm
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          Description
          OverviewCa2+ chelator exhibiting a 105-fold greater affinity for Ca2+ (Kd = 110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Useful for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.
          Catalogue Number196418
          Brand Family Calbiochem®
          Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
          References
          ReferencesDeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Li, L., et al. 1995. J. Cell Physiol. 163, 105.
          Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.
          Product Information
          CAS number126824-24-6
          FormOff-white solid
          Hill FormulaC₂₂H₂₀N₂O₁₀ · 4Na
          Chemical formulaC₂₂H₂₀N₂O₁₀ · 4Na
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          196418

          References

          Reference overview
          DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Li, L., et al. 1995. J. Cell Physiol. 163, 105.
          Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
          DescriptionCa2+-chelator exhibiting a 105-fold greater affinity for Ca2+ (110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Has been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.
          FormOff-white solid
          CAS number126824-24-6
          Chemical formulaC₂₂H₂₀N₂O₁₀ · 4Na
          Structure formulaStructure formula
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesDeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Li, L., et al. 1995. J. Cell Physiol. 163, 105.
          Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Chelating Agents