196419 BAPTA/AM - CAS 126150-97-8 - Calbiochem

196419
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₄₀N₂O₁₈ 126150-97-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      196419-100MG
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          Plastic ampoule 100 mg
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          196419-25MG
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              Plastic ampoule 25 mg
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              Description
              OverviewMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
              Catalogue Number196419
              Brand Family Calbiochem®
              Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
              References
              ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
              Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
              Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
              Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
              Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
              Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
              Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
              Tsien, R.Y. 1981. Nature 290, 527.
              Tsien, R.Y. 1980. Biochemistry 19, 2396.
              Product Information
              CAS number126150-97-8
              FormLight yellow solid
              Hill FormulaC₃₄H₄₀N₂O₁₈
              Chemical formulaC₃₄H₄₀N₂O₁₈
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥90% by TLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              196419

              References

              Reference overview
              Bissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
              Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
              Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
              Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
              Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
              Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
              Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
              Tsien, R.Y. 1981. Nature 290, 527.
              Tsien, R.Y. 1980. Biochemistry 19, 2396.

              Brochure

              Title
              Calcium Metabolism and Related Products Brochure

              Citations

              Title
            • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
            • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-April-2008 RFH
              Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
              DescriptionMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
              FormLight yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number126150-97-8
              Chemical formulaC₃₄H₄₀N₂O₁₈
              Structure formulaStructure formula
              Purity≥90% by TLC
              SolubilityDMSO (10 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Irritant
              ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
              Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
              Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
              Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
              Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
              Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
              Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
              Tsien, R.Y. 1981. Nature 290, 527.
              Tsien, R.Y. 1980. Biochemistry 19, 2396.
              Citation
            • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
            • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
            • Related Products & Applications

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Chelating Agents