189510 Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem

189510
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₃₄NO₄PNa₂ • 2H₂O 1103672-43-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189510-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~ 6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
          Catalogue Number189510
          Brand Family Calbiochem®
          SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
          References
          ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
          Samadi, N., et al. 2009. Oncogene 28, 1028.
          Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
          Product Information
          CAS number1103672-43-0
          FormWhite powder
          Hill FormulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
          Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189510

          References

          Reference overview
          Boutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
          Samadi, N., et al. 2009. Oncogene 28, 1028.
          Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-March-2011 RFH
          SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
          DescriptionA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1103672-43-0
          Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (0.5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Regulatory Review
          ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
          Samadi, N., et al. 2009. Oncogene 28, 1028.
          Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.